SAN FRANCISCO — As more states 
embrace legalized marijuana,
 the drug’s growing medicinal use has highlighted a disturbing fact for 
doctors: scant research exists to support marijuana’s health benefits.
Smoked, eaten or brewed as a tea, marijuana has been used as a 
medication for centuries, including in the United States, where Eli 
Lilly sold it until 1915. The drug was declared illegal in 1937, though 
its long history has provided ample anecdotal evidence of the plant’s 
potential medicinal use. Still, modern scientific studies are lacking.
What’s more, the federal government is scaling back its research 
funding. U.S. spending has dropped 31 percent since 2007 when it peaked 
at $131 million, according to a National Institutes of Health research 
database. Last year, 235 projects received $91 million of public funds, 
according to NIH data.
That’s left the 
 medical community in
 a bind: current literature on the effects of medical cannabis is 
contradictory at best, providing little guidance for prescribing 
doctors.
“What’s happening in the states is not related to science at all,” 
said Donald Vereen, a former adviser to the last three directors of the 
National Institute on Drug Abuse.
“It’s difficult to get good information,” said Beau Kilmer, co-director of 
RAND Corp.’s drug policy research center. Kilmer is also part of a group selected to advise the state of Washington on its legalization effort.
Two states, 
Washington and Colorado, have fully legalized the drug. A 
 bill in the Maine Legislature calls for a statewide referendum to fully legalized and tax marijuana use for other than medical reasons.
A 
federal bill,
 co-sponsored by U.S. Rep. Chellie Pingree, a Democrat who represents 
Maine’s 1st District, would no longer define marijuana use as a federal 
crime.
Eighteen states, including Maine allow its use for medical reasons 
and 17, including New York, have legislation pending to legalize it.
Vereen, the NIDA adviser, says that most doctors’ and policymakers’ knowledge on the subject stems from a 1999 report from the 
Institute of Medicine,
 an independent nonprofit that serves to provide information about 
health science for the government. The group summed up its findings 
saying cannabis appeared to have benefits, though the drug’s role was 
unclear.
The 
IOM report
 recommended clinical trials of cannabinoid drugs for anxiety reduction,
 appetite stimulation, nausea reduction and pain relief. It also found 
that the brain develops tolerance to marijuana though the withdrawal 
symptoms are “mild compared to opiates and benzodiazapines.”
“We don’t know that much more than what’s in that report,” said Vereen.
Vereen, for one, says marijuana’s effects on pain without the 
withdrawal symptoms associated with other medications are deserving of 
further study to develop better pain drugs.
Subsequent research suggests marijuana may help stimulate appetite in
 chemotherapy and AIDS patients, help improve muscle spasms in multiple 
sclerosis patients, mitigate nerve pain in those with HIV-related nerve 
damage and reduce depression and anxiety. It’s even been suggested that 
an active ingredient, THC, may prevent plaques in the brain associated 
with Alzheimer’s, according to a 2006 study by the 
Scripps Research Institute.
Still, fewer than 20 randomized controlled trials, the gold standard 
for clinical research, involving only about 300 patients have been 
conducted on smoked marijuana over the last 35 years, according to the 
American Medical Association, the U.S.’s largest doctor group.
A few small companies are trying to tap into an emerging market for 
marijuana therapies, which could exceed $1 billion in California alone, 
according to Mickey Martin, director of T-Comp Consulting in Oakland, 
Calif., which advises people who want to set up their own cannabis 
businesses.
His model of about 750,000 cannabis patients found that the estimated
 spending from California’s patient population is $1.1 billion, 
including $56 million in doctors’ fees and about $1 billion in medicine.
 That assumes roughly two-thirds of the patient population will pay $40 a
 week for medication, Martin said. 
Cannabis Science Inc.,
 CannaVest Corp., and Medical Marijuana Inc. are among a handful of 
companies developing drugs based on cannabis research or medical 
marijuana itself.
Until more laws change, it will be difficult to study an illegal 
substance with the goal of turning it into a medication, researchers 
say. And since it’s illegal to grow, marijuana isn’t subjected to the 
rigorous quality control most medicines are, raising concerns patients 
may be at risk from contaminants, said Vereen.
Marijuana advocates point out inherent obstacles to conducting 
research: the National Institute on Drug Abuse controls all the cannabis
 used in approved trials, but the agency’s mandate is to study abuse of 
drugs, not health benefits.
This creates dilemmas. 
The Food and Drug Administration,
 for instance, has approved a clinical trial studying whether marijuana 
can relieve symptoms of post-traumatic stress disorder. The trial, 
however, which is in the second of three stages of clinical testing, is 
blocked. NIDA, which controls the legal testing supply of the drug grown
 at a University of Mississippi farm, has refused to supply the 
researchers with marijuana.
“NIDA is under a mandate from Congress to find problems with 
marijuana,” said Bob Melamede, CEO of Cannabis Science Inc., a Colorado 
Springs, Colo.-based company that develops medicines derived from 
marijuana. “If you want to run a study to show it cures cancer, they 
will not provide you with marijuana,” he said. “What you cannot do are 
the clinical studies that are necessary.”
Attempts to expand licensed facilities beyond the University of 
Mississippi farm, have been denied, including a petition from University
 of Massachusetts agronomist Lyle Craker. The Drug Enforcement 
Administration denied that request in 2011, reversing a 2007 
recommendation from its own administrative law judge, Mary Ellen 
Bittner.
NIDA also administered the most projects from 2003 to 2012, 
overseeing $713 million split among 1,837 research efforts. The bulk of 
the funding in the past decade was devoted to evaluating marijuana’s 
risks, potential negative impacts on the brain and developing prevention
 and treatment strategies, according to NIDA.
“There’s been a significant amount of study, but not clinical research,” said Brad Burge, a spokesman for the 
Multidisciplinary Association for Psychedelic Studies,
 a non- profit research and advocacy group. What’s lacking, says Burge, 
is “research intended to move marijuana, the plant, through the path to 
prescription approval by the FDA.”
For now, the research that does exist is often contradictory. A 
survey of 4,400 people found that those who consumed marijuana daily or 
at least once a week reported less depressed mood than non-users, 
according to a 2005 report in the journal 
Addictive Behaviors.
 A 2010, however, study in the American Journal of Drug and Alcohol 
Abuse of 14,000 found that anxiety and mood disorders were more common 
in those who smoked almost every day or daily.
Still, people continue to swear by medical marijuana. Cathy Jordan, 
63, was diagnosed with amyotrophic lateral sclerosis at 36 and given 3 
to 5 years to live. She smoked marijuana, a strain called Myakka Gold, 
on a Florida beach with friends, and from that day “the disease just 
stopped,” said her husband Bob, 65.
“All cannabis seems to work, and it’s slowed the progression,” he 
said in a telephone interview. They think marijuana may interfere with a
 neurotransmitter, glutamate, that can have harmful effects in the 
disease “but we’re just guessing here. All we know is when she doesn’t 
have it, she gets sick and when she does have it, she doesn’t get sick.”
On Feb. 25, they were raided for growing 23 plants for Cathy’s use. 
Bob was charged, though the prosecutors declined to press charges 
because of the medical records the couple supplied, he said. Currently, 
Cathy is the president of FL CAN, an advocacy group meant to generate 
support for changing marijuana policies.
Doctors’ attitudes are also shifting in favor of easing marijuana 
restrictions. The American Medical Association, the nation’s biggest 
doctor organization has called for a review of marijuana’s Schedule I 
status, a designation that declares it has no accepted medical use.
The American College of Physicians, the second-largest U.S. doctor 
organization with 133,000 members, also wants criminal penalties waived 
for doctors who prescribe marijuana and patients who smoke it. The drug 
could be useful to treat multiple sclerosis, nausea and pain, based on 
preliminary studies and pre-clinical lab work, the group said in a 
2008 position paper calling for more research.
For the first time, a majority of Americans say they support legalization, according to a survey released April 4 by the 
Pew Research Center.
As those views trickle up to law makers, there’s little doubt that 
the easing of marijuana restrictions on the state level will continue.
“We are in the middle of the river,” said Roger Roffman, a professor 
emeritus at the University of Washington’s school of social work who has
 studied marijuana use more than 20 years. “Change is happening so 
rapidly with both medical marijuana and non-medical marijuana, that it 
is too early to know what’s likely happening in terms of the effect.”
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